Which fundamental organs can be affected by systemic effects of toxic materials?

The systemic effects of toxic materials primarily impact organs that have a crucial role in maintaining overall bodily functions. The heart, brain, and kidneys are essential organs that can be significantly affected by toxins due to their critical roles in the circulatory, nervous, and excretory systems.

The heart is vital for pumping blood and distributing oxygen and nutrients throughout the body, and exposure to toxic materials can lead to cardiovascular issues. The brain, as the control center of the nervous system, can be adversely affected by neurotoxins, which might disrupt cognitive or motor functions. The kidneys play an important role in filtering the blood, and they can be harmed by various toxins, leading to impaired waste removal and potential renal failure.

In contrast, while the liver and lungs are indeed involved in processing toxins, the liver primarily handles metabolic processes, and the lungs are essential for gas exchange, options involving those organs did not include the decisive combination of organs that represent significant systemic impacts as thoroughly as the heart, brain, and kidneys do. Similarly, muscles, bones, nerves, eyes, ears, and the stomach also have their own relevance, but they lack the integrative critical functions tied to systemic effects from toxic exposure when compared to the selected correct answer.